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Vash’s gun is a .45 Long Colt Revolver. He got it from his brother Knives. Knives has a black version of this gun. These two guns are larger, heavier and stronger than normal guns. Vash’s gun also has some text on it which translates into: EF Auto Ejecting Double Action.
Nicholas D. Wolfwood, a wandering priest, always carries a wrapped up cross. But this wrapping covered the Cross Punisher. It held his original weapons, eight .45 caliber automatic handguns inside. After taking the cloth off, the horizontal side bars slide out, revealing the eight guns. Wolfwood eventually replaced it with the Cross Punisher II. It sounds like it would be the same as the Cross Punisher, but it no longer holds the weapons. It is the weapon. One side, the longer side, contains one wicked machine gun. The other side holds a grenade launcher.
"Derringer" Meryl Strife was given that nickname because she carries Derringer pistols, each with only two bullets. To make up for the lack of ammunition, she carries atleast 50 of these pistols.
"Stungun" Milly Thompson carries one large, very heavy weapon. People sometimes stare in awe as Milly carries it around or slings it over her shoulder. This gun fires large cylinders that split to for a cross and then pin the unfortunate soul to the ground.
Vash the Stampede and Millions Knives both have another awesome gun. It’s the weapon that destroyed July City and Augusta . Only Knives and Vash have this gun, it is activated by shooting the front of their .45 revolvers off. This happens with a beautiful bright light. After that, the arm transforms in a huge, gun like thing. In the middle is a ball of energy, this is where the beam starts. In city of July, the Vash's Angel Arm destroyed the buildings in the city, but left the people alive.